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Is Zoloft safe while breastfeeding?
Sertraline (Zoloft) is the most-studied antidepressant in breastfeeding mothers. The amount reaching milk is small, and infant blood levels are usually too low to detect, which is why the NIH's LactMed database and ACOG both place it among the preferred choices during lactation.
Medically reviewed by Dr. Akinwande Akintola, MD — Sun Jul 19 2026
Sertraline (Zoloft) is the most-studied antidepressant in breastfeeding mothers. The amount reaching milk is small, and infant blood levels are usually too low to detect, which is why the NIH's LactMed database and ACOG both place it among the preferred choices during lactation.
Already on it before delivery? Continuing is generally simpler and safer than switching or stopping. We wrote the full evidence walk-through, including the medications that aren't first picks: Zoloft and breastfeeding.
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